Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure ∗
نویسندگان
چکیده
منابع مشابه
Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure.
SEE PAGE 559 W ith limited capacity to store adenosine triphosphate (ATP) in the form of glycogen and phosphocreatine, the heart is continuously dependent on ATP synthesis to maintain force generation, myofibrillar relaxation, and ionic homeostasis. The ability of normal myocardium to adapt its substrate use to meet these essential demands has been appreciated for over half a century. Central i...
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Cardiac energetic impairment is a feature of systolic heart failure irrespective of the underlying etiology, and the magnitude of this impairment is predictive of subsequent mortality. It is also a feature of other forms of heart muscle diseases including hypertrophic cardiomyopathy and heart failure with normal ejection fraction. While the adult heart normally uses predominantly free fatty aci...
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ژورنال
عنوان ژورنال: JACC: Heart Failure
سال: 2016
ISSN: 2213-1779
DOI: 10.1016/j.jchf.2016.03.008